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Cavernous sinus thrombosis is a blood clot in the cavernous sinus. The cavernous sinus is a cavity at the base of the brain that contains a vein, several nerves, and other structures. The vein carries deoxygenated blood from the brain and face back to the heart.

The vein and cavity run between the large bone at the base of the skull (sphenoid bone) and temporal bone (near the temple).

The cause of cavernous sinus thrombosis is usually a bacterial infection that has spread from the sinuses, ears, eyes, nose, or skin of the face.

• Bulging eyeballs
• Cannot move the eye in a particular direction
• Drooping eyelids
• Vision loss

Tests that may be ordered include:

• CT scan of the head
• Magnetic resonance imaging (MRI) of the brain
• Sinus x-ray

Cavernous sinus thrombosis is treated with high-dose intravenous (through a vein) antibiotics. Sometimes surgery is needed to drain the infection.

Cavernous sinus thrombosis can be fatal. However, the death rate of this condition has improved tremendously since the introduction of antibiotics.

Call your doctor right away if you have:

• Bulging of your eyes
• Drooping eyelids
• Eye pain
  • Inability to move your eye in any particular direction
  • Vision loss

Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: WB Saunders; 2007:2717.

Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.